Pharmacogenomics and schizophrenia: clinical implications
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چکیده
منابع مشابه
Pharmacogenomics and Opioid Analgesics: Clinical Implications
Variation exists in patient response on analgesic treatment in terms of efficacy and safety. This variation may be in part explained by pharmacogenomics. This paper aimed to review data on pharmacogenomics of opioid analgesics focusing on the effect of genetic variation on the efficacy and safety of these agents. Current evidence suggests that pharmacogenomics contribute to variation in efficac...
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Despite advances and investments in translation research, clinical trials and health service in general, there is no significant impact on the survival of most patients diagnosed with advanced pancreatic adenocarcinoma. It is broadly recognized though that there is a small minority of patients who really benefit from particular treatments for reason usually not well understood. Light to this fa...
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Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is inco...
متن کاملClinical Implications of Opioid Pharmacogenomics in Patients With Cancer.
BACKGROUND Pain can be a significant burden for patients with cancer and may have negative effects on their quality of life. Opioids are potent analgesics and serve as a foundation for pain management. The variation in response to opioid analgesics is well characterized and is partly due to genetic variability. METHODS We reviewed the results of clinical studies to evaluate the relationships ...
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The Promise of Pharmacogenomics As genomic medicine advances, there is hope that genetic biomarkers will encourage movement away from empirical and population-based treatment approaches to those that are stratified according to better patient outcomes, thus ending a “trial-and-error” approach to therapy.4,6–8 It is estimated that only 50% of patients respond positively to their medications.5,9 ...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2001
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500038